4-(N-Boc-amino)phenylboronic acid is an aromatic boronic acid building block with a tert-butoxycarbonyl-protected amino group. Listed under CAS 380430-49-9, it is used chiefly as a bifunctional intermediate in organic synthesis, including Suzuki–Miyaura cross-coupling routes where the boronic acid can form a carbon–carbon bond while the protected amine is retained for later use. Its molecular formula is C11H16BNO4, and its molecular weight is approximately 237.06 g/mol. For buyers, the key points are to confirm the exact chemical identity, review the lot-specific certificate of analysis, and match packaging and documentation to the intended project.
The molecule combines two useful features on a benzene ring: a boronic acid group and an N-Boc-protected amino group positioned para to one another. The Boc group is a protecting group that temporarily masks the amine, which can help chemists carry that functionality through selected reaction steps. The boronic acid group can participate in reactions that form carbon–carbon bonds, with Suzuki–Miyaura coupling being a common example. The compound is therefore a versatile intermediate rather than a finished pharmaceutical ingredient.
Its name may also appear in supplier and research materials as 4-(tert-butoxycarbonylamino)phenylboronic acid or 4-(Boc-amino)phenylboronic acid. These names describe the same general structure, but buyers should not rely on a product name alone when placing an order. Confirm CAS 380430-49-9, the molecular formula, and the structure or product identifier against the supplier’s documentation. The CAS number identifies the substance; it does not, by itself, establish a particular purity grade or specification.
The aryl boronic acid group makes this compound useful as a coupling partner for preparing substituted aromatic compounds. In a suitable reaction system, the boronic acid-bearing phenyl ring can be joined to another organic fragment, while the Boc-protected amino group remains available for subsequent steps. The actual reaction outcome depends on the substrate, catalyst, base, solvent, and process conditions selected by the chemist. Buyers should therefore assess the material against their route rather than assume that one set of conditions applies to every project.
The Boc-protected amino group can serve as a latent amine that may be unmasked at a later stage, if the planned chemistry supports deprotection. This can be helpful when a free amine could interfere with an earlier reaction or complicate purification. In medicinal chemistry and pharmaceutical intermediate development, such building blocks may be evaluated during the synthesis of candidate molecules or route intermediates. Use in a synthesis does not mean the substance is approved for pharmaceutical use, and regulatory status must be assessed for the specific application.
The product requested here is the boronic acid, not automatically a boronic ester or another derivative. Related compounds, such as pinacol esters, may have different identifiers, formulas, handling characteristics, and behavior in a synthesis. A buyer should specify the required form explicitly and verify it against the supplier’s product description and analytical documents. If a project can use more than one form, compare them experimentally and evaluate the effect on reaction performance, work-up, and storage needs.
Product grade and supply format can also differ between suppliers and lots. Rather than assuming that a catalog listing implies a universal specification, ask which test methods and acceptance criteria apply to the offered material. Where a project requires a specific impurity profile, residual-solvent limit, or other control, communicate that requirement before requesting a quotation. The supplier should confirm whether it can meet the stated requirements for the particular lot.
For an initial technical review, compare the product identity and analytical information shown in the quotation, specification sheet, and certificate of analysis. The following fields are practical starting points; the appropriate limits depend on your process and must be agreed with the supplier. We recommend treating any stated value as lot-specific unless the supplier confirms otherwise. For research or process development, request enough documentation to connect the material received with the lot that was tested.
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| Specification field | What to check | Why it matters |
|---|---|---|
| Identity | Product name, CAS 380430-49-9, formula C11H16BNO4, and structure | Helps distinguish the boronic acid from related derivatives and protected or unprotected analogues. |
| Molecular weight | Approximately 237.06 g/mol | Supports stoichiometric calculations and cross-checking of the stated identity. |
| Assay or purity | Reported result, method, and agreed acceptance limit | Provides a basis for assessing whether a lot is suitable for the intended use. |
| Appearance and physical form | Lot description and any stated acceptance criteria | Allows comparison with the specification and supports receiving inspection. |
| Packaging and storage | Container, net quantity, storage instructions, and handling information | Helps maintain traceability and plan receipt, storage, and use. |
Do not infer a guaranteed shelf life, storage temperature, or purity from the chemical name alone. Follow the supplier’s current safety data sheet and lot documentation, and ask for clarification if the stated handling conditions do not fit your facility. A certificate of analysis should be reviewed for the reported result, test method where provided, and lot number. If you require additional testing, specify it during the inquiry so feasibility can be confirmed before purchase.
Start by defining the information your quality or technical team needs: identity confirmation, lot-specific analytical results, safety documentation, and traceability. For regulated or scale-up work, check whether the supplier can provide the documents and change-control communication required by your internal procedures. Do not assume a supplier’s general capabilities automatically apply to every product or order. Confirm product-specific documentation before committing to a schedule.
State the amount required in grams or kilograms, the intended delivery destination, and whether the purchase is for evaluation, development, or ongoing supply. Ask the supplier to confirm available quantity, packaging options, lead time, and quotation validity for the requested order. These details can vary with inventory and production planning, so they should be verified for each inquiry rather than treated as fixed public specifications. If you anticipate repeat demand, discuss forecast ranges and resupply expectations early.
A suitable supplier should be able to confirm what is being offered and respond clearly to questions about the specification, analytical methods, packaging, and shipping documents. Compare quotations on more than unit price: assess identity assurance, documentation, order flexibility, communication, and delivery terms together. If your synthesis has a sensitive impurity or performance requirement, share the relevant acceptance criteria before ordering. This allows both parties to identify gaps before material is shipped.
At Maison Chemical, we support B2B inquiries for 4-(N-Boc-amino)phenylboronic acid CAS 380430-49-9 by helping buyers clarify the required identity, quantity, documentation, and delivery details. We can review the requested specification and confirm the information available for the offered lot as part of the quotation process. Availability, packaging, lead time, and documentation should be confirmed for each order. This approach helps procurement and technical teams assess the material against their own project requirements without relying on assumptions.
When contacting us, include your required quantity, destination, target delivery schedule, and any special analytical or document requirements. If you are evaluating the compound for a particular synthetic route, you may also tell us whether you need a research quantity or a larger development supply. We can then respond with the applicable product and commercial information for review. Final suitability should be determined by your technical and quality teams using the lot documentation and your process requirements.
In short, this compound is a protected aminophenyl boronic acid building block for organic synthesis, and the right sourcing decision depends on matching a verified lot to your technical and procurement requirements. The practical next step is to request a quotation with your required quantity and specification, then review the available certificate of analysis and safety documentation before ordering. Contact Maison Chemical with those details to discuss product availability and B2B supply options.
Contact us to discuss your requirements of 4-(N-Boc-amino)phenylboronic acid CAS 380430-49-9. Our experienced sales team can help you identify the options that best suit your needs.
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