When I evaluate 1-Methyl-4-pyrazole boronic acid pinacol ester, CAS 761446-44-0, I treat it as a specialized boronic ester intermediate for medicinal chemistry and pharmaceutical research. The most important buying checks are identity, assay or purity, water content, appearance, analytical traceability, packaging, and the supplier’s ability to provide consistent documentation. I recommend confirming every numerical specification against the current product specification and COA because commercial requirements can differ by application, batch size, and intended process.
I prepared this guide for procurement teams, process chemists, medicinal chemistry groups, contract research organizations, and pharmaceutical intermediate buyers. It is also relevant to distributors that need a traceable source for small laboratory quantities or larger project-based requirements. The information is intended to support supplier screening and quotation discussions, not to replace internal quality, safety, or regulatory review.
Buyers may encounter different commercial grades, pack sizes, and release criteria for the same CAS number. A research-use purchase may focus on rapid availability and analytical data, while a process-development purchase may require tighter control of impurities, water, residual solvents, and packaging. I therefore recommend defining the intended use before requesting a quotation.
1-Methyl-4-pyrazole boronic acid pinacol ester is a boronic ester containing a methyl-substituted pyrazole ring and a pinacol-protected boron group. In synthetic chemistry, the boronic ester functionality is commonly selected as a coupling handle for constructing carbon-carbon bonds, including Suzuki-type cross-coupling strategies when the reaction system is suitable. Actual reactivity depends on the substrate, catalyst, base, solvent, temperature, and process conditions.
The material is generally handled as a specialty organic intermediate rather than as a finished pharmaceutical ingredient. Its exact physical form, color, stability, and handling requirements should be confirmed from the current SDS, specification sheet, and batch COA supplied for the material. I do not recommend assuming that a literature procedure will transfer directly to production without laboratory and process validation.
The first specification check is whether the product name, CAS number, structure, and molecular information are consistent across the quotation, label, SDS, specification, and COA. The commonly referenced molecular formula is C10H17BN2O2, and the approximate molecular weight is 208.07 g/mol. Because catalog records and internal systems can contain transcription differences, I ask the supplier to confirm the structure and analytical identity before approval.
Identity testing may be supported by techniques such as proton NMR, carbon NMR, mass spectrometry, or another method defined in the supplier’s quality system. The COA should state the actual method or provide a clear reference to the applicable test procedure. For a new supplier, I prefer reviewing representative analytical data rather than relying only on a product name and CAS number.
Purity may be reported by HPLC, GC, NMR, or another validated or qualified internal method, depending on the material and the supplier’s release practice. These methods are not interchangeable, so I compare results only when the test method and calculation basis are clear. I also ask whether the reported value is an area percentage, assay percentage, or another measurement with a defined basis.
Related substances can be especially important when the material will enter a multi-step synthesis. Potential concerns may include unreacted starting material, hydrolysis products, regioisomeric impurities, pinacol-related components, or residual process impurities. I recommend asking for an impurity profile or agreed limits when the intermediate is intended for process development rather than one-time screening.
Boronic esters can be sensitive to storage and handling conditions, and water content may influence both material quality and reaction performance. A buyer may request Karl Fischer water testing where moisture control is relevant; for example, a project specification could set a limit such as not more than 1.0%, but I would never treat that value as a universal standard without written agreement. The actual limit should reflect the chemistry, packaging, and customer process.
Residual solvents should be evaluated against the buyer’s internal requirements and applicable process expectations. The COA may report selected solvents, a total residual-solvent result, or a statement based on the supplier’s release procedure. Appearance is also useful as a screening attribute, but visual inspection alone cannot confirm identity or purity.
| Review Area | What I Ask the Supplier to Confirm |
|---|---|
| Identity | CAS number, chemical name, structure, and analytical identity method |
| Purity or assay | Test method, result format, specification limit, and batch result |
| Water content | Whether Karl Fischer testing is available and what limit applies |
| Residual solvents | Tested solvents, reporting basis, and customer-specific limits |
| Packaging | Container type, seal, protection from moisture, and labeling details |
A useful COA should connect the test results to a specific manufacturing batch. I check the product name, CAS number, batch or lot number, manufacturing date where available, test date, specification limits, actual results, analytical methods, and authorized quality approval. A document that lists only a generic purity claim without batch traceability provides limited support for technical purchasing.
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I also compare the COA with the label and shipping documents before accepting the material. The container label should identify the same product and batch shown on the COA, while the packaging should be appropriate for the stated storage conditions. If a buyer requires a specific format, such as a customer template, impurity table, or additional analytical spectrum, that request should be made before order confirmation.
For discovery-scale work, I usually prioritize verified identity, practical pack sizes, consistent purity reporting, and fast technical communication. A buyer may not need an extensive process impurity package for an early route screen, but the team still needs enough information to weigh the material accurately and interpret unexpected reaction results. A small sample or development pack can help confirm suitability before a larger purchase.
For process work, I place more emphasis on batch-to-batch consistency, impurity control, water content, residual solvents, packaging, and supply continuity. I also recommend discussing whether the supplier can provide a pre-shipment COA, retain samples, and a change-notification approach where appropriate. These details can reduce avoidable delays when a synthetic route moves from laboratory experimentation toward a larger campaign.
Distributors and recurring buyers should evaluate commercial stability in addition to laboratory quality. Important questions include standard MOQ, available stock, production lead time, shelf-life or retest policy, export documentation, and the ability to support repeat lots. I recommend recording these points in the approved supplier file rather than relying only on informal quotation messages.
The price of CAS 761446-44-0 can vary with purity requirements, order quantity, packaging, production status, testing scope, and shipping destination. I avoid comparing quotations by unit price alone because a lower price may exclude additional analytical testing, special packaging, or documentation requested by the buyer. A clear RFQ should state the target quantity, grade, delivery location, required documents, and desired delivery window.
MOQ is supplier- and package-dependent, so I ask for both a sample option and a production-scale option when possible. Lead time should be separated into stock availability, preparation or manufacturing time, quality release time, and transit time. If a project is schedule-sensitive, I recommend confirming the shipping date in writing and requesting early notice if the planned batch or release timing changes.
As a specialty chemicals manufacturer and supplier, I at Maison Chemical support buyer discussions around product identification, specification alignment, COA review, packaging, and shipment planning for 1-Methyl-4-pyrazole boronic acid pinacol ester CAS 761446-44-0. Available support depends on the requested quantity, destination, and agreed quality requirements, so I encourage buyers to provide their application and documentation needs at the inquiry stage. This approach allows us to prepare a more relevant quotation instead of offering a generic price only.
One common mistake is treating the CAS number as a complete quality specification. The CAS number helps identify the substance, but it does not by itself define purity, water content, residual solvents, packaging, or batch consistency. Another mistake is requesting a quotation without stating whether the material is for screening, process development, manufacturing support, or distribution.
I also advise against approving a supplier based only on a catalog image or an unqualified purity statement. Buyers should check whether the COA is batch-specific and whether the analytical method matches the project’s expectations. Finally, storage and handling instructions should be reviewed with the SDS and internal safety procedures before the material is received.
The best way to source 1-Methyl-4-pyrazole boronic acid pinacol ester CAS 761446-44-0 is to evaluate the complete supply package: verified identity, transparent specifications, batch-linked COA, suitable packaging, realistic lead time, and responsive technical support. I recommend beginning with a defined RFQ that includes quantity, intended use, purity expectations, required tests, destination, and documentation requirements. After reviewing the supplier’s response, use a sample or initial batch to confirm fit with your internal analytical and synthetic workflow.
If you are comparing sources for research, process development, or regular procurement, Maison Chemical can discuss the product specification, COA requirements, packaging options, MOQ, and delivery planning with you. Send your target quantity, destination, and required quality documents so I can help prepare a practical B2B quotation and sourcing recommendation.
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