4-Trifluoromethylphenylboronic acid, also called 4-(trifluoromethyl)phenylboronic acid, is an aryl boronic acid used primarily as a coupling partner in organic synthesis. Its chemical identifiers include CAS Number 128796-39-4, molecular formula C7H6BF3O2, and a calculated molecular weight of approximately 189.93 g/mol. At Maison Chemical, we support B2B buyers evaluating this intermediate for medicinal chemistry, agrochemical research, specialty synthesis, and other laboratory-scale or process-development applications.
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The most important purchasing decision is not simply whether the material is available. Buyers should confirm identity, assay, impurity profile, packaging, storage conditions, batch documentation, and the supplier’s ability to support repeat orders. The following guide explains the compound’s role, selection criteria, supplier evaluation points, and practical next steps without overstating data that must be confirmed by a current certificate of analysis.
This reference is intended for procurement teams, process chemists, medicinal chemists, formulation researchers, distributors, and laboratory managers sourcing organic boronic acids. It is especially relevant when a project requires a defined aryl substituent rather than a general phenylboronic acid. The information can also help buyers compare suppliers before requesting samples or production quantities.
Because application requirements differ, this page should be used as a purchasing and technical-screening guide rather than as a substitute for reaction-specific validation. Reaction performance depends on the coupling partner, catalyst system, base, solvent, concentration, temperature, work-up, and purification method. We recommend evaluating the material against the exact requirements of the intended process.
| Item | Information |
|---|---|
| Common name | 4-Trifluoromethylphenylboronic acid |
| Alternative name | 4-(Trifluoromethyl)phenylboronic acid |
| CAS Number | 128796-39-4 |
| Molecular formula | C7H6BF3O2 |
| Approximate molecular weight | 189.93 g/mol |
| Functional class | Aryl boronic acid and fluorinated aromatic building block |
The molecule contains an aryl boronic acid group and a para-trifluoromethyl substituent on the aromatic ring. The boronic acid functionality is the reactive site commonly used in palladium-catalyzed cross-coupling, while the trifluoromethyl group remains incorporated into the coupled product. This combination makes the compound useful when a synthesis requires both a transferable aryl group and a fluorinated substituent.
Product appearance, purity, water content, and stability should be confirmed from the supplier’s current batch documentation. We avoid treating a general catalog description as a substitute for lot-specific evidence, because physical characteristics and analytical results can vary with manufacturing route, drying conditions, packaging, and storage history.
Commercial material may be offered in different package sizes and quality grades, such as research-use quantities, development quantities, or larger technical supply. The correct option depends on the buyer’s intended scale and quality system. A small discovery project may prioritize rapid availability and a suitable analytical package, while process development may require tighter control of trace impurities and a documented supply plan.
Before approval, I recommend comparing the following specifications with the project’s internal requirements:
A stated purity percentage should always be interpreted together with the analytical method and specification basis. For example, an HPLC assay and a quantitative NMR result may not describe exactly the same measurement. If the material will enter a regulated or tightly controlled process, buyers should also clarify whether the supplier can provide supporting documents such as a safety data sheet, certificate of analysis, and declaration of origin where applicable.
The principal use of 4-trifluoromethylphenylboronic acid is as an aryl donor in Suzuki–Miyaura coupling with a suitable aryl or heteroaryl halide, pseudohalide, or related electrophile. This reaction can create biaryl or heteroaryl–aryl structures that contain a para-trifluoromethyl group. Actual conversion and selectivity must be established experimentally for each substrate combination.
Fluorinated aromatic groups are frequently explored in pharmaceutical and agrochemical research because fluorine substitution can modify molecular properties such as lipophilicity, metabolic behavior, and electronic distribution. These effects are structure-dependent and should not be interpreted as a guaranteed performance advantage. In practice, this boronic acid is most useful as a modular intermediate for preparing and screening diversified compound libraries.
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The compound may also be considered in the synthesis of functional aromatic molecules, reference compounds, and process-development intermediates. Its suitability depends on the target structure and the tolerance of the planned chemistry to boron-containing impurities, residual metals, and work-up conditions. Buyers should discuss the intended route with the technical supplier when the material is needed for scale-up rather than exploratory synthesis.
Start by stating whether the product is intended for reaction screening, medicinal chemistry, process development, manufacturing, or resale. This determines the appropriate documentation, pack size, acceptance criteria, and supply continuity expectations. It also helps the supplier recommend a realistic quantity and delivery plan.
Match the CAS number, molecular formula, molecular weight, and requested nomenclature across the purchase order, specification sheet, label, and COA. Ask whether the supplier can provide chromatographic, spectroscopic, or other identity data appropriate to the material. If a project has limits for water, residual solvents, palladium, or other trace elements, include those limits before quotation.
Minimum order quantity and lead time vary according to inventory status, package size, production scheduling, and export destination. Rather than relying on a generic estimate, request a current quotation that states available stock, production lead time, shipping terms, and quotation validity. For planning purposes, provide the required quantity in grams or kilograms and indicate whether repeat supply is expected.
A qualified supplier should be able to answer basic questions about lot traceability, packaging, documentation, and complaint handling. Buyers should also confirm whether the quoted product is manufactured, stocked, or sourced through another channel. Clear communication about these points reduces the risk of receiving a material that meets the name description but does not meet the project specification.
One frequent mistake is selecting a product solely by CAS number without checking the required purity basis or analytical method. Another is postponing discussion of packaging and storage until after the order has been confirmed. A third is assuming that material suitable for exploratory chemistry automatically meets process or regulated procurement requirements.
Buyers should also avoid comparing quotations only by price per gram. A lower unit price may not represent better value if the order has a long lead time, limited documentation, unsuitable packaging, or inconsistent batch support. A complete comparison should include delivered cost, quantity, quality evidence, payment terms, logistics, and the supplier’s ability to support the next order.
At Maison Chemical, we treat 4-Trifluoromethylphenylboronic acid as a technical sourcing requirement rather than a simple catalog transaction. We can discuss the intended application, requested quantity, target specification, packaging preference, destination, and documentation needs before preparing a quotation. This approach helps us distinguish a discovery-scale request from a development or repeat-supply project.
We also encourage buyers to request lot-specific information before approval. Depending on the order and application, the documentation package may include product identification, COA information, SDS, packaging details, and shipping conditions that are applicable to the quoted batch. Availability and lead time should be confirmed at the time of inquiry because they can change with inventory and production scheduling.
4-Trifluoromethylphenylboronic acid CAS 128796-39-4 is a fluorinated aryl boronic acid used mainly to introduce a 4-trifluoromethylphenyl group through cross-coupling and related synthetic routes. Its key verified identifiers include formula C7H6BF3O2 and approximate molecular weight 189.93 g/mol. The best supplier decision combines chemical identity with evidence on purity, documentation, packaging, availability, and repeat-order capability.
If you are evaluating this material for a specific synthesis or procurement program, send Maison Chemical the required quantity, target specification, application, and destination. We can then review the request and provide a practical quotation with current availability and applicable technical documents.
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